Adrenocortical Sensitivity to ACTH in Neonatal Rats : 3 4 Correlation of Corticosterone Responses and Adrenal cAMP Content 5 6 7 8 9
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چکیده
1 2 Adrenocortical Sensitivity to ACTH in Neonatal Rats: 3 4 Correlation of Corticosterone Responses and Adrenal cAMP Content 5 6 7 8 9 Jonathan Bodager, Thomas Gessert, Eric D. Bruder, Ashley Gehrand and Hershel Raff 10 11 12 13 Endocrine Research Laboratory; Aurora St. Luke's Medical Center, Aurora Research Institute, 14 Milwaukee, WI 53215 15 16 and 17 18 Departments of Medicine, Surgery, and Physiology, Medical College of Wisconsin, Milwaukee, 19 Wisconsin, 53226 20 21 Short Title: Adrenal sensitivity to ACTH 22 23 24 25 26 Correspondence: 27 Hershel Raff, PhD 28 Endocrinology 29 Aurora St. Luke’s Medical Center 3
منابع مشابه
Adrenocortical sensitivity to ACTH in neonatal rats: correlation of corticosterone responses and adrenal cAMP content.
A coordinated hypothalamic-pituitary-adrenal axis response is important for the survival of newborns during stress. We have previously shown that prior to postnatal day (PD) 5, neonatal rats exposed to hypoxia (one of the most common stressors effecting premature neonates) exhibit a large corticosterone response with a minimal increase in immunoassayable plasma ACTH and without a detectable inc...
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We have previously demonstrated that the neonatal corticosterone response to acute hypoxia shifts from ACTH independence to ACTH dependence between postnatal days two (PD2) and eight (PD8). Cyclic AMP (cAMP) is the obligatory intracellular second messenger of ACTH action, and we hypothesized that corticosterone production in neonatal rats shifts from a cAMP-independent mechanism to cAMP-depende...
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The adrenocortical response to hypoxia may be a critical component of the adaptation to this common neonatal stress. Little is known about adrenal function in vivo in hypoxic neonates. The purpose of this study was to evaluate adrenocortical responses to ACTH in suckling rat pups exposed to hypoxia from birth to 5-7 days of age, compared to normoxic controls. We also evaluated potential cellula...
متن کاملAdrenocortical responses to ACTH in neonatal rats: effect of hypoxia from birth on corticosterone, StAR, and PBR.
The adrenocortical response to hypoxia may be a critical component of the adaptation to this common neonatal stress. Little is known about adrenal function in vivo in hypoxic neonates. The purpose of this study was to evaluate adrenocortical responses to ACTH in suckling rat pups exposed to hypoxia from birth to 5-7 days of age compared with normoxic controls. We also evaluated potential cellul...
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Hypoxia is a common cause of neonatal morbidity and mortality. We have previously demonstrated a dramatic ACTH-independent activation of adrenal steroidogenesis in hypoxic neonatal rats, leading to increases in circulating corticosterone levels. The purpose of the present study was to determine if this ACTH-independent increase in corticosterone inhibits the ACTH response to acute stimuli. Neon...
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